李欢,男,中共党员,博士,副教授,硕士研究生导师,山东预防医学会卫生毒理分会委员,山东生物医学工程学会委员,山东省健康促进与教育学会常务委员,山东省大数据研究会公共卫生分会委员,济宁市工伤预防培训专家库专家。2021年毕业于山西医科大学劳动卫生与环境卫生学专业。主要承担职业卫生与职业医学、卫生学、职业卫生评价、卫生工程学、分子毒理学技术等课程的教学工作。近年来,主要从事化学物神经毒性的研究工作,参与国家自然科学基金面上项目1项,主持山东省自然科学基金项目1项、贺林院士新医学临床转化工作站项目1项、济宁医学院高层次培育计划项目1项。发表论文30余篇,其中SCI论文19篇,第一作者或通讯作者9篇。获山西省优秀博士学位论文奖。
近五年代表性科研项目:
1. miR-128-3p通过调控Sirt1/Nrf2/keap1信号通路参与铝致认知障碍的机制研究(ZR2022QH114),山东省自然科学基金项目,2023.01.01-2025.12.30,主持,15万元;
2. PINK1/Parkin 通路介导的线粒体自噬在铝致认知障碍中的作用及机制研究(JYHL2022 MS06),贺林院士新医学临床转化工作站科研基金项目,2023.01.01-2025.12.30,主持,10万元;
3. miR-124-3p通过调控STAT3-TGF-β1/Smad3信号通路参与铝致认知障碍的机制研究(JYGC2023KJ004),济宁医学院高层次科研项目培育计划立项项目,2024.01.01-2026.12.30,主持,10万元;
4. 铝致认知功能损害的机制研究(600941001),济宁医学院博士科研启动基金,2022.01.01-2026.12.30,主持,68万元;
近五年代表性成果:
1. Huan Li*, Yan Liu, Xiangmeng Wang, Chaoqun Xu, Xiaoyu Zhang, Jing Zhang, Li Lin, Qiao Niu*. miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway. Ecotoxicol Environ Saf. 2024 Feb: 271:115966.
2. Huan Li, Qinli Zhang, Xingli Xue, Jingsi Zhang, Shanshan Wang, Jing Zhang, Li Lin, Qiao Niu*, Lnc001209 Participates in aluminium-induced apoptosis of PC12 cells by regulating PI3K-AKT-mTOR signalling pathway. Ecotoxicol Environ Saf. 2023 Jul 1; 259:115062.
3. Huan Li, Qun Liu, Qinli Zhang, Xingli Xue, Jingsi Zhang, Jing Zhang, Li Lin, Qiao Niu*, miR-200a-3p Regulates PRKACB and Participates in Aluminium-Induced Tau Phosphorylation in PC12 Cells. Neurotox Res. 2022 Dec;40(6):1963-1978.
4. Huan Li1, Qun Liu1, Liang Li, Xiujun Qin, ShanShan Wang, Jiali Hu, Xiaoting Lu, Jing Song, JiSheng Nie, Qinli Zhang, Linping Wang*, Qiao Niu* Aluminum inhibits non-amyloid pathways via retinoic acid receptor. J Trace Elem Med Biol. 2022 Jan; 69:126902.
5. Huan Li1, Qun Liu1, Xingli Xue, Xiaoting Lu, Jing Song, Chanting He, Yanxia Hao, Jisheng Nie, Qinli Zhang, Yue Zhao, Baolong Pan, Linping Wang*, Qiao Niu*, miR-29a/b1 Regulates BACE1 in Aluminum-Induced Aβ Deposition in Vitro. ACS Chem Neurosci. 2021 Sep 1;12(17):3250-3265.
6. Huan Li, Xingli Xue, Liang Li, Yaqin Li, Yanni Wang, Tao Huang, Yanhong Wang, Huaxing Meng, Baolong Pan, Qiao Niu*. Aluminium-induced synaptic plasticity impairment via PI3K-AKT-mTOR signaling pathway[J]. Neurotoxicity research, 2020 Apr; 37(4):996-1008. (cover article, SCI, IF=3.311).
7. Huan Li, Xingli Xue, Zhaoyang Li, Baolong Pan, Yanxia Hao, Qiao Niu*. Aluminium-induced synaptic plasticity injury via the PHF8–H3K9me2-BDNF signalling pathway[J]. Chemosphere, 2020 Apr; 244:125445. (SCI, IF=5.108).
8. Huan Li, Tao Huang, Yanhong Wang, Baolong Pan, Ling Zhang, Qinli Zhang, Qiao Niu*. Alumina nanoparticles affect immune system regulation in mice[J]. Nanomedicine, 2020 Apr; 15(9):927-946. (SCI, IF=4.717).
9. Yanni Wang#, Huan Li#, Jingsi Zhang, Yingchao Han, Jing Song, Linping Wang, Yanxia Hao, Chanting He, Jisheng Nie, Qinli Zhang, Xiaoting Lu*, Qiao Niu*, Effect of aluminum combined with ApoEε4 on Tau phosphorylation and Aβ deposition[J]. Journal of trace elements in medicine and biology. 2020 Dec 01;64. (SCI, IF=3.245).